Title : Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability.

Pub. Date : 2012 Jan 20

PMID : 22139843






2 Functional Relationships(s)
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1 To better understand turnover and identify potential sites of Cx43 ubiquitination, we prepared constructs of Cx43 with different lysines converted to arginines. Lysine gap junction protein alpha 1 Homo sapiens
2 However, when transfected into cells, a mutant version of Cx43 with all lysines converted to arginines behaved similarly to wild type in the presence of proteasomal and lysosomal inhibitors, indicating that ubiquitination of Cx43 did not appear to be playing a role in gap junction stability. Lysine gap junction protein alpha 1 Homo sapiens