Title : Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.

Pub. Date : 2012 Jan 15

PMID : 22128299






1 Functional Relationships(s)
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1 Interestingly, increasing the Noxa/Mcl-1 ratio, by decreasing Mcl-1 (dasatinib and roscovitine) or increasing Noxa levels (fludarabine and bortezomib), resulted in synergy with ABT-737. fludarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens