Title : Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography.

Pub. Date : 2012 Mar

PMID : 22126621






1 Functional Relationships(s)
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1 Based on KRAS mutation status, a strong correlation was found between (111)In-DOTA-cetuximab tumor uptake and EGFR expression level (KRAS wild type: r = 0.988; KRAS mutant: r = 0.829), and between (64)Cu-DOTA-cetuximab tumor uptake with EGFR expression level (KRAS wild type: r = 0.838; KRAS mutant: r = 0.927). 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid epidermal growth factor receptor Homo sapiens