Pub. Date : 2012 Apr
PMID : 22126602
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Y654 of beta-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of beta-catenin. | Tyrosine | catenin beta 1 | Homo sapiens |
| 2 | Tyrosine phosphorylation of beta-catenin affects the cell adhesion, migration, and gene transcription in many types of human cancer cells, including acute myeloid leukemia cells with FLT3 internal tandem duplication (FLT3/ITD-AML). | Tyrosine | catenin beta 1 | Homo sapiens |
| 3 | Here, we investigated the relationship between three tyrosine residues (Y86, Y142, and Y654) in beta-catenin and oncogenic FLT3/ITD kinase. | Tyrosine | catenin beta 1 | Homo sapiens |
| 4 | These results explain how FLT3/ITD affects the tyrosine phosphorylation, nuclear localization, and transcriptional activity of beta-catenin. | Tyrosine | catenin beta 1 | Homo sapiens |