Title : Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade.

Pub. Date : 2012 Feb

PMID : 22118570






2 Functional Relationships(s)
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1 Resveratrol preferentially inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation upon LPS stimulation by interfering with IKK and IkappaB phosphorylation, an effect that potently reduced the transcriptional stimulation of several NF-kappaB target genes, including tumor necrosis factor-alpha and interleukin-6. Resveratrol interleukin 6 Homo sapiens
2 Resveratrol treatment also prevented the pro-inflammatory effect of fibrillar Abeta on macrophages by potently inhibiting the effect of Abeta on IkappaB phosphorylation, activation of STAT1 and STAT3, and on tumor necrosis factor-alpha and interleukin-6 secretion. Resveratrol interleukin 6 Homo sapiens