Title : Effects of natural products on the function of human organic anion transporting polypeptide 1B1.

Pub. Date : 2012 Apr

PMID : 22117525






2 Functional Relationships(s)
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1 At a concentration of 100 muM, 42 natural products inhibited OATP1B1-mediated [(3)H]E3S uptake by more than 50%, and five of them significantly inhibited OATP1B1-mediated [(3)H]E3S by more than 80% with the following rank order of potency: quercetin > astragaloside IV > icariin > glycyrrhizic acid > ginsenoside Rc. ginsenoside Rc solute carrier organic anion transporter family member 1B1 Homo sapiens
2 At a concentration of 100 muM, 42 natural products inhibited OATP1B1-mediated [(3)H]E3S uptake by more than 50%, and five of them significantly inhibited OATP1B1-mediated [(3)H]E3S by more than 80% with the following rank order of potency: quercetin > astragaloside IV > icariin > glycyrrhizic acid > ginsenoside Rc. ginsenoside Rc solute carrier organic anion transporter family member 1B1 Homo sapiens