Title : NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus.

Pub. Date : 2012 Feb 15

PMID : 22114025






1 Functional Relationships(s)
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1 In this study, we investigated the relationship between ROS and the nongenomic actions of MR. We examined the nongenomic actions of MR by measuring the slope of the field excitatory postsynaptic potentials and found that ROS induced an additive increase of these potentials, which was accompanied by Rac1 GTP activation and ERK1/2 phosphorylation. Reactive Oxygen Species Rac family small GTPase 1 Rattus norvegicus