Title : Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice.

Pub. Date : 2012

PMID : 22110479






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1 We previously demonstrated in streptozotocin-induced diabetic mice that deficiency or inhibition of aldose reductase (AR) caused significant dephosphorylation of hepatic transcriptional factor PPARalpha, leading to its activation and significant reductions in serum lipid levels. Streptozocin peroxisome proliferator activated receptor alpha Mus musculus