Pub. Date : 2011 Nov
PMID : 22110186
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-kappaB/mTOR signaling. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Abrogation of AKT which regulates both NF-kappaB and mTOR increased the sensitivity of tumor cells to CDDO-Me. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Thus, these data showing strong growth-inhibitory and apoptosis-inducing activity of CDDO-Me for ovarian cancer cells through the inhibition of AKT/ NF-kappaB/mTOR signaling pathway provide basis for evaluation of CDDO-Me for ovarian cancer. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |