Title : DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts.

Pub. Date : 2011 Dec 20

PMID : 22106305






6 Functional Relationships(s)
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1 Repair of the breaks after NaCl is reduced is accompanied by formation of foci containing phosphorylated H2AX (gammaH2AX), which occurs around DNA double-strand breaks and contributes to their repair. Sodium Chloride H2A.X variant histone Mus musculus
2 Repair of the breaks after NaCl is reduced is accompanied by formation of foci containing phosphorylated H2AX (gammaH2AX), which occurs around DNA double-strand breaks and contributes to their repair. Sodium Chloride H2A.X variant histone Mus musculus
3 By chromatin immunoprecipitation using anti-gammaH2AX antibody, followed by massive parallel sequencing (ChIP-Seq), we find that during repair of double-strand breaks induced by high NaCl, gammaH2AX is predominantly localized to regions of the genome devoid of genes ("gene deserts"), indicating that the high NaCl-induced double-strand breaks are located there. Sodium Chloride H2A.X variant histone Mus musculus
4 By chromatin immunoprecipitation using anti-gammaH2AX antibody, followed by massive parallel sequencing (ChIP-Seq), we find that during repair of double-strand breaks induced by high NaCl, gammaH2AX is predominantly localized to regions of the genome devoid of genes ("gene deserts"), indicating that the high NaCl-induced double-strand breaks are located there. Sodium Chloride H2A.X variant histone Mus musculus
5 By chromatin immunoprecipitation using anti-gammaH2AX antibody, followed by massive parallel sequencing (ChIP-Seq), we find that during repair of double-strand breaks induced by high NaCl, gammaH2AX is predominantly localized to regions of the genome devoid of genes ("gene deserts"), indicating that the high NaCl-induced double-strand breaks are located there. Sodium Chloride H2A.X variant histone Mus musculus
6 By chromatin immunoprecipitation using anti-gammaH2AX antibody, followed by massive parallel sequencing (ChIP-Seq), we find that during repair of double-strand breaks induced by high NaCl, gammaH2AX is predominantly localized to regions of the genome devoid of genes ("gene deserts"), indicating that the high NaCl-induced double-strand breaks are located there. Sodium Chloride H2A.X variant histone Mus musculus