Pub. Date : 2011
PMID : 22102901
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Galectin-3 (Gal-3) and active (GTP-bound) K-Ras contribute to the malignant phenotype of many human tumors by increasing the rate of cell proliferation, survival, and migration. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | These Gal-3-mediated effects result from a selective binding to K-Ras.GTP, causing increased nanoclustering in the cell membrane and leading to robust Ras signaling. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | We found that knockout of Gal-3 induced strong downregulation (~60%) of K-Ras and K-Ras.GTP. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | These additional effects are probably attributable to inhibition of the weak interactions of K-Ras.GTP with Gal-1. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |