Title : Methodological Advances Permit the Stereocontrolled Construction of Diverse Fully Synthetic Tetracyclines Containing an All-Carbon Quaternary Center at Position C5a.

Pub. Date : 2011 Dec 23

PMID : 22102762






1 Functional Relationships(s)
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1 Two compounds prepared from the bridged cyclopropane intermediate served as (further) diversifiable branch-points, allowing maximally expedient synthesis of C5a-substituted tetracyclines by final-step diversification. cyclopropane complement C5a receptor 1 Homo sapiens