Pub. Date : 2012 Feb
PMID : 22102173
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small cell lung cancer. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 2 | PURPOSE: To investigate the association between a single-nucleotide polymorphism (SNP) of ERCC1, Asn118Asn (C T), and the response of patients with late-stage non-small cell lung cancer (NSCLC) (n = 142) to cisplatin-based chemotherapy. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 3 | CONCLUSIONS: Our results suggest that this polymorphism of ERCC1 at codon 118 is associated with patient response to cisplatin-based chemotherapy in treatments of late-stage NSCLC. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |