Title : DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity.

Pub. Date : 2012 Feb

PMID : 22095831






1 Functional Relationships(s)
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1 We found that both DHA and EPA suppress the expression and activity of Delta5- and Delta6-desaturases, leading to decreased flux through the n-3 and n-6 PUFA metabolic pathways and decreased production of AA. Docosahexaenoic Acids fatty acid desaturase 1 Homo sapiens