Protein Name fatty acid desaturase 1
Organism Homo sapiens
Gene ID 3992
Gene Symbol


UniProt O60427 (FADS1_HUMAN), A0A0A0MR51 (A0A0A0MR51_HUMAN)
Relationships Total Number of functionally related compound(s) : 160
Total Number of Articles : 250

fatty acid desaturase 1

Gene Summary

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]

  • acyl-CoA (8-3)-desaturase
  • delta(5) desaturase
  • delta-5 fatty acid desaturase
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