Pub. Date : 2012 Mar
PMID : 22086152
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased ERK activation and cellular drug accumulation in the enhanced cytotoxicity of folate receptor-targeted liposomal carboplatin. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | To elucidate this discrepancy, activation of extracellular signal-regulated protein kinase (ERK) was probed, which has been suggested as an alternative mechanism of carboplatin action. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | FRT liposomes loaded with carboplatin exhibited the highest level of ERK phosphorylation, and the cytotoxic effect of FRT carboplatin liposomes could be reversed by the MEK/ERK inhibitors, U0126 and PD98059. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | FRT liposomes loaded with carboplatin exhibited the highest level of ERK phosphorylation, and the cytotoxic effect of FRT carboplatin liposomes could be reversed by the MEK/ERK inhibitors, U0126 and PD98059. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | FRT liposomes loaded with carboplatin exhibited the highest level of ERK phosphorylation, and the cytotoxic effect of FRT carboplatin liposomes could be reversed by the MEK/ERK inhibitors, U0126 and PD98059. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | FRT liposomes loaded with carboplatin exhibited the highest level of ERK phosphorylation, and the cytotoxic effect of FRT carboplatin liposomes could be reversed by the MEK/ERK inhibitors, U0126 and PD98059. | Carboplatin | mitogen-activated protein kinase 1 | Homo sapiens |