Title : Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.

Pub. Date : 2012 Feb

PMID : 22085833






3 Functional Relationships(s)
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1 Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation. Galantamine nitric oxide synthase 2 Homo sapiens
2 Furthermore, galantamine reduced iNOS induction and production of NO caused by OGD via Jak2. Galantamine nitric oxide synthase 2 Homo sapiens
3 In conclusion, galantamine afforded neuroprotection under OGD-reoxygenation conditions by activating a signaling pathway that involves nicotinic receptors, Jak2 and the consequent inhibition of NOX and NFkappaB/iNOS. Galantamine nitric oxide synthase 2 Homo sapiens