Title : Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine A₁ receptors.

Pub. Date : 2012 Jan 15

PMID : 22085758






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1 Caffeine reversal of acetaminophen results from actions in the spinal cord, as intrathecal DPCPX 10 nmol inhibited antinociception by systemic acetaminophen; this was also observed in +/+ but not in -/- adenosine A(1) receptor mice. Caffeine adenosine A1 receptor Mus musculus