Title : Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic K(ATP) channel.

Pub. Date : 2012 Mar

PMID : 22083559






1 Functional Relationships(s)
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1 Kir and SUR were transiently coexpressed in HEK cells and [(3)H]glibenclamide binding and patch-clamp experiments were performed in whole cells at 37 C and in isolated inside/out patches at 22 C. Truncation of the first 5 N-terminal amino acids abolished most of the affinity increase for glibenclamide and repaglinide that is produced by the association of Kir6.2 with SUR1. repaglinide killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens