Protein Name killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Organism Homo sapiens
Gene ID 3805
Gene Symbol


UniProt Q99706 (KI2L4_HUMAN), A0A0B4J1S6 (A0A0B4J1S6_HUMAN), A0A376A929 (A0A376A929_HUMAN)
Relationships Total Number of functionally related compound(s) : 240
Total Number of Articles : 358

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

Gene Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]

  • killer cell immunoglobulin-like receptor 2DL4
  • CD158 antigen-like family member D
  • KIR2DL4 Killer-cell Immunoglobulin-like Receptor
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