Title : A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.

Pub. Date : 2011 Nov 13

PMID : 22082911






2 Functional Relationships(s)
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1 Here we report the mechanism of action of a small molecule that inhibits O-linked N-acetylglucosamine transferase (OGT), an essential human enzyme that modulates cell signaling pathways by catalyzing a unique intracellular post-translational modification, beta-O-GlcNAcylation. beta-o O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens
2 Here we report the mechanism of action of a small molecule that inhibits O-linked N-acetylglucosamine transferase (OGT), an essential human enzyme that modulates cell signaling pathways by catalyzing a unique intracellular post-translational modification, beta-O-GlcNAcylation. beta-o O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens