Title : Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS.

Pub. Date : 2012 Jan

PMID : 22082652






2 Functional Relationships(s)
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1 METHODS: Accumulation of nevirapine was assessed in parental and ABCC10-transfected HEK293 cells (HEK293-ABCC10), CD4+ cells, and monocyte-derived macrophages from healthy volunteers (n=8). Nevirapine CD4 molecule Homo sapiens
2 After small interfering RNA knockdown of ABCC10, there was an increase in accumulation of nevirapine in CD4 cells (32%; P=0.03) and monocyte-derived macrophages (38%; P=0.04). Nevirapine CD4 molecule Homo sapiens