Title : Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

Pub. Date : 2012 Apr

PMID : 22067624






1 Functional Relationships(s)
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1 CONCLUSIONS: Mild hypothermia reduces the systemic clearances of fentanyl and midazolam in rats after cardiac arrest through alterations in cytochrome P450 3a2 metabolic capacity rather than enzyme affinity as observed with other cytochrome P450s. Fentanyl cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus