Pub. Date : 2011 Nov 7
PMID : 22061047
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | Sphingolipids | haptoglobin-related protein | Homo sapiens |
| 2 | Ceramide and, more recently, other sphingolipid species (e.g., dihydroceramide and dihydrosphingosine) have been implicated in 4-HPR-mediated tumor cell death. | Sphingolipids | haptoglobin-related protein | Homo sapiens |
| 3 | Because sphingolipid metabolism has been reported to be altered in drug-resistant tumor cells, we studied the implication of sphingolipids in acquired resistance to 4-HPR based on an acute lymphoblastic leukemia model. | Sphingolipids | haptoglobin-related protein | Homo sapiens |
| 4 | CCRF-CEM cell lines resistant to 4-HPR exhibited a distinctive endogenous sphingolipid profile that correlated with inhibition of dihydroceramide desaturase. | Sphingolipids | haptoglobin-related protein | Homo sapiens |
| 5 | Therapeutically, the data demonstrate that alternative sphingolipid-modulating antitumoral strategies are suitable for both 4-HPR-resistant and sensitive leukemia cells. | Sphingolipids | haptoglobin-related protein | Homo sapiens |