Title : Tuning HP1α chromodomain selectivity for di- and trimethyllysine.

Pub. Date : 2011 Dec 16

PMID : 22052799






1 Functional Relationships(s)
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1 The selectivity of HP1alpha chromodomain for H3K9Me(3) over H3K9Me(2) was investigated by mutating E52 to remove or weaken the hydrogen bond to K9Me(2) while maintaining affinity for K9Me(3,) including E52F, E52I, E52V, E52D, an E52Q. Hydrogen Suppressor of variegation 205 Drosophila melanogaster