Pub. Date : 2012 Apr
PMID : 22042506
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study aimed to evaluate the protective effect of isorhynchophylline, an oxindole alkaloid isolated from a Chinese herb Uncaria rhynchophylla, on Abeta-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. | rhyncophylline | amyloid beta precursor protein | Rattus norvegicus |
| 2 | The results showed that pretreatment with isorhynchophylline significantly elevated cell viability, decreased the levels of intracellular reactive oxygen species and malondialdehyde, increased the level of glutathione, and stabilized mitochondrial membrane potential in Abeta(25-35)-treated PC12 cells. | rhyncophylline | amyloid beta precursor protein | Rattus norvegicus |
| 3 | These results indicate that isorhynchophylline exerts a neuroprotective effect against Abeta(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial pathway of cellular apoptosis. | rhyncophylline | amyloid beta precursor protein | Rattus norvegicus |