Pub. Date : 2012 Feb
PMID : 22038047
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 2 | Since caveolin-1 (Cav-1) plays a role in AMPK activation and energy balance, we investigated whether Cav-1 could participate in metformin"s inhibitory effect on IGF1 signaling. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 3 | In Calu-1, but not in Calu-6 cells, metformin reduced phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR) substrates Akt and Forkhead transcription factor 3a (FOXO3a), inhibited IGF1-dependent FOXO3a nuclear exit, and decreased IGF1-dependent cell proliferation. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 4 | In Calu-1, but not in Calu-6 cells, metformin reduced phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR) substrates Akt and Forkhead transcription factor 3a (FOXO3a), inhibited IGF1-dependent FOXO3a nuclear exit, and decreased IGF1-dependent cell proliferation. | Metformin | insulin like growth factor 1 | Homo sapiens |
| 5 | Cav-1 silencing in Calu-1 and overexpression in Calu-6 reduced and improved, respectively, the inhibitory effect of metformin on IGF1-dependent Akt phosphorylation. | Metformin | insulin like growth factor 1 | Homo sapiens |