PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22038047-0	2012	Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.	Metformin	28-37	insulin like growth factor 1	Homo sapiens	59-63	
22038047-2	2012	Since caveolin-1 (Cav-1) plays a role in AMPK activation and energy balance, we investigated whether Cav-1 could participate in metformin"s inhibitory effect on IGF1 signaling.	Metformin	128-137	insulin like growth factor 1	Homo sapiens	161-165	
22038047-4	2012	In Calu-1, but not in Calu-6 cells, metformin reduced phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR) substrates Akt and Forkhead transcription factor 3a (FOXO3a), inhibited IGF1-dependent FOXO3a nuclear exit, and decreased IGF1-dependent cell proliferation.	Metformin	36-45	insulin like growth factor 1	Homo sapiens	197-201	
22038047-4	2012	In Calu-1, but not in Calu-6 cells, metformin reduced phosphorylation of type 1 insulin-like growth factor receptor (IGF-IR) substrates Akt and Forkhead transcription factor 3a (FOXO3a), inhibited IGF1-dependent FOXO3a nuclear exit, and decreased IGF1-dependent cell proliferation.	Metformin	36-45	insulin like growth factor 1	Homo sapiens	247-251	
22038047-6	2012	Cav-1 silencing in Calu-1 and overexpression in Calu-6 reduced and improved, respectively, the inhibitory effect of metformin on IGF1-dependent Akt phosphorylation.	Metformin	116-125	insulin like growth factor 1	Homo sapiens	129-133