Pub. Date : 2012 May
PMID : 22037925
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of PI3K, GSK-3beta and PPARgamma in the antidepressant-like effect of folic acid in the forced swimming test in mice. | Folic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | pre-treatment of mice with LY294002 (10 nmol/site, a PI3K inhibitor) or GW-9662 (1 microg/site, a PPARgamma antagonist) prevented the antidepressant-like effect of folic acid (50 mg/kg, p.o.) | Folic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | These results indicate that the antidepressant-like effect of folic acid in the FST might be dependent on inhibition of GSK-3beta and activation of PPARgamma, reinforcing the notion that these are important targets for antidepressant activity. | Folic Acid | peroxisome proliferator activated receptor gamma | Mus musculus |