Pub. Date : 2012 Feb
PMID : 22036635
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BCR-ABL1 kinase-positive leukemia cells accumulate high numbers of DNA double-strand breaks (DSBs) induced by the reactive oxygen species (ROS) or cytotoxic agents. | dsbs | BCR activator of RhoGEF and GTPase | Homo sapiens |
| 2 | Moreover, Ac-H3 and Ac-H4 readily co-localized with the spontaneous and mitomycin C-induced DSBs in BCR-ABL1-positive leukemia cells suggesting that histone acetylation and chromatin re-modeling is important for efficient repair of numerous DSBs. | dsbs | BCR activator of RhoGEF and GTPase | Homo sapiens |