Pub. Date : 2012 Jan
PMID : 22033021
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. | Isatin | caspase 3 | Mus musculus | ||
| 2 | We evaluated the ability of radiolabeled isatins to quantify caspase-3 activity induced by the activation of the extrinsic apoptotic pathway by the anti-Fas antibody in mice. | Isatin | caspase 3 | Mus musculus | ||
| 3 | The isatin [(18)F]WC-II-89 was retained at statistically significantly higher levels in the organs after anti-Fas antibody treatment while [(99m)Tc]mebrofenin activity cleared, suggesting specific binding to activated caspase-3, but the magnitude of increased binding was still relatively low. | Isatin | caspase 3 | Mus musculus | ||
| 4 | CONCLUSIONS: The radiolabeled isatins appear to bind specifically to caspase-3 in vivo, but their sensitivity is limited. | Isatin | caspase 3 | Mus musculus | ||