Pub. Date : 2011 Oct 26
PMID : 22029423
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RSV enhanced IR-induced expression of DNA damage (gammaH2Ax) and apoptosis (cleaved-caspase 3) markers as well as of the cell cycle regulators p53, p21(cip1) and p27(kip1). | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | CONCLUSIONS: Our results suggest that RSV arrests cell cycle, promotes apoptosis and sensitizes PrCa cells to IR likely through a desirable dual action to activate the ATM-AMPK-p53-p21(cip1)/p27(kip1) and inhibit the Akt signalling pathways. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |