Pub. Date : 2012 Feb
PMID : 22023848
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, the role of PKC in morphine-induced rewarding memory was investigated using the conditioned place preference (CPP) model. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | Furthermore, the PKC translocation inhibitor gammaV5-3 impaired the morphine-induced CPP when microinjected into the NAc. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | These findings indicated that PKC, especially the gamma isoform, is essential for the acquisition and maintenance of morphine-associated reward memory. | Morphine | protein kinase C, gamma | Rattus norvegicus |