PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22023848-2 2012 In the present study, the role of PKC in morphine-induced rewarding memory was investigated using the conditioned place preference (CPP) model. Morphine 41-49 protein kinase C, gamma Rattus norvegicus 34-37 22023848-5 2012 Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. Morphine 84-92 protein kinase C, gamma Rattus norvegicus 35-43 22023848-5 2012 Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. Morphine 143-151 protein kinase C, gamma Rattus norvegicus 35-43 22023848-5 2012 Specifically, the protein level of PKCgamma in membrane of the NAc was increased in morphine CPP rats, and decreased during the attenuation of morphine-induced CPP, while the protein level of PKCgamma in cytosol of the NAc showed an opposite change. Morphine 143-151 protein kinase C, gamma Rattus norvegicus 192-200 22023848-6 2012 Furthermore, the PKC translocation inhibitor gammaV5-3 impaired the morphine-induced CPP when microinjected into the NAc. Morphine 68-76 protein kinase C, gamma Rattus norvegicus 17-20 22023848-7 2012 These findings indicated that PKC, especially the gamma isoform, is essential for the acquisition and maintenance of morphine-associated reward memory. Morphine 117-125 protein kinase C, gamma Rattus norvegicus 30-33