Title : Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.

Pub. Date : 2011 Nov

PMID : 22023129






1 Functional Relationships(s)
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1 CONCLUSIONS AND CLINICAL RELEVANCE: Human-specific inhibitors of CYP2A6, CYP2C19, CYP3A4, CYP2B6, and CYP2C9 diminished ketamine N-demethylation in dogs and horses. ketamine n cytochrome P450 family 2 subfamily C member 9 Homo sapiens