Pub. Date : 2011
PMID : 22022384
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of A375 and Hs294t cells with EGCG resulted in a dose-dependent inhibition of cell migration or invasion of these cells, which was associated with a reduction in the levels of cyclooxygenase (COX)-2, prostaglandin (PG) E(2) and PGE(2) receptors (EP2 and EP4). | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | EGCG inhibits 12-O-tetradecanoylphorbol-13-acetate-, an inducer of COX-2, and PGE(2)-induced cell migration of cells. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Moreover, EGCG inhibited the activation of NF-kappaB/p65, an upstream regulator of COX-2, in A375 melanoma cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, also inhibited cell migration. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Together, these results indicate that EGCG, a major green tea catechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of COX-2, PGE(2) receptors and epithelial-to-mesenchymal transition. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |