PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22022384-4	2011	Treatment of A375 and Hs294t cells with EGCG resulted in a dose-dependent inhibition of cell migration or invasion of these cells, which was associated with a reduction in the levels of cyclooxygenase (COX)-2, prostaglandin (PG) E(2) and PGE(2) receptors (EP2 and EP4).	epigallocatechin gallate	40-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-208	
22022384-6	2011	EGCG inhibits 12-O-tetradecanoylphorbol-13-acetate-, an inducer of COX-2, and PGE(2)-induced cell migration of cells.	epigallocatechin gallate	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72	
22022384-8	2011	Moreover, EGCG inhibited the activation of NF-kappaB/p65, an upstream regulator of COX-2, in A375 melanoma cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, also inhibited cell migration.	epigallocatechin gallate	10-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88	
22022384-10	2011	Together, these results indicate that EGCG, a major green tea catechin, has the ability to inhibit melanoma cell invasion/migration, an essential step of metastasis, by targeting the endogenous expression of COX-2, PGE(2) receptors and epithelial-to-mesenchymal transition.	epigallocatechin gallate	38-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	208-213