Title : TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells.

Pub. Date : 2012 Feb

PMID : 22020547






1 Functional Relationships(s)
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1 Our results showed that the TPA-induced up-regulation of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor), but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although TPA increased the phosphorylation of ERK and JNK in MCF-7 cells. U 0126 mitogen-activated protein kinase 8 Homo sapiens