Title : Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer.

Pub. Date : 2011 Dec

PMID : 22019170






3 Functional Relationships(s)
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1 Paclitaxel induces apoptosis through activation of nuclear protein kinase C-delta and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer. Paclitaxel cyclin dependent kinase 1 Homo sapiens
2 Data revealed that paclitaxel induced an increase of Cdk1 activity and DR5 expression on the Golgi complex that was associated with increased cleavage of caspase-8, a DR5 downstream factor, and caspase-3 into catalytically active fragments. Paclitaxel cyclin dependent kinase 1 Homo sapiens
3 CONCLUSIONS: Data suggest that paclitaxel induces nuclear translocation and activation of PKC-delta, which in turn causes Golgi-Cdk1 activation, leading to Golgi associated DR5 up-regulation, and caspase-8 and 3 activation. Paclitaxel cyclin dependent kinase 1 Homo sapiens