Pub. Date : 2012 Jan 1
PMID : 22016432
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aberrant expression of both ASBT and CDXs in Barrett"s esophagus (BE) prompted us to study, whether the expression of the ASBT gene is regulated by CDXs. | cdxs | solute carrier family 10 member 2 | Homo sapiens |
| 2 | Short interfering RNA-mediated knockdown of CDXs resulted in reduced ASBT mRNA expression in intestinal cells. | cdxs | solute carrier family 10 member 2 | Homo sapiens |
| 3 | CDXs strongly induced the activity of the ASBT promoter in reporter assays in esophageal and intestinal cells. | cdxs | solute carrier family 10 member 2 | Homo sapiens |
| 4 | Nine CDX binding sites were predicted in silico within the ASBT promoter, and binding of CDXs to six of them was verified in vitro and within living cells by electrophoretic mobility shift assays and chromatin immunoprecipitation assays, respectively. | cdxs | solute carrier family 10 member 2 | Homo sapiens |