Title : Periocular injection of in situ hydrogels containing Leu-Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury.

Pub. Date : 2011 Dec

PMID : 22001716






3 Functional Relationships(s)
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1 The dipeptide leucine-isoleucine (Leu-Ile) appears to induce the production of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), in the brain. Dipeptides brain-derived neurotrophic factor Rattus norvegicus
2 The dipeptide leucine-isoleucine (Leu-Ile) appears to induce the production of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), in the brain. Dipeptides brain-derived neurotrophic factor Rattus norvegicus
3 We therefore administered Leu-Ile via periocular depot injection in rats and investigated the dipeptide"s ability to induce BDNF and GDNF in the retina and to delay RGC loss in an ON injury model. Dipeptides brain-derived neurotrophic factor Rattus norvegicus