Title : Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor.

Pub. Date : 2012

PMID : 21997473






2 Functional Relationships(s)
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Protein Name
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1 We were interested in studying the C-terminal heparin-binding region of FN since it mediates aggrecan and type II collagen breakdown in cartilage, but the specific FN domains responsible for proteolytic enzyme activity and their receptors in cartilage are unknown. Heparin fibronectin 1 Mus musculus
2 We found that the FN III 13-14 domains in the C-terminal heparin-binding region of FN are potent inducers of aggrecanase activity in articular cartilage. Heparin fibronectin 1 Mus musculus