Title : Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.

Pub. Date : 2011 Dec

PMID : 21993412






3 Functional Relationships(s)
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1 Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. 4-cresol mitogen-activated protein kinase 1 Homo sapiens
2 P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets. 4-cresol mitogen-activated protein kinase 1 Homo sapiens
3 These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production. 4-cresol mitogen-activated protein kinase 1 Homo sapiens