Pub. Date : 2011 Oct 12
PMID : 21992677
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells. | parthenolide | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation. | parthenolide | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Since we previously showed that parthenolide inhibits excessive IL-8 production by CF cells, we evaluated its effects on MAPK and AP-1 activation and showed that parthenolide inhibited ERK and AP-1 activation. | parthenolide | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Parthenolide inhibited both NFkappaB and MAPK/AP-1 pathways contributing to the inhibition of IL-8 production. | parthenolide | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |