Title : Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride.

Pub. Date : 2011 Dec 19

PMID : 21989207






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures. Oximes acetylcholinesterase Cavia porcellus