PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21989207-3 2011 Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures. Oximes 49-54 acetylcholinesterase Cavia porcellus 212-216