Title : Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.

Pub. Date : 2012 Mar

PMID : 21983886






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Microsomal epoxide hydrolase, EPHX1, plays a central role in the detoxification of potentially genotoxic epoxide intermediates. Epoxy Compounds epoxide hydrolase 1 Homo sapiens
2 In conclusion, individuals with EPHX1 113His/His slow activity genotype may not detoxify reactive carcinogenic epoxides efficiently, binding of reactive epoxides to DNA cause DNA damage. Epoxy Compounds epoxide hydrolase 1 Homo sapiens