Title : Polyphosphate is a cofactor for the activation of factor XI by thrombin.

Pub. Date : 2011 Dec 22

PMID : 21976677






3 Functional Relationships(s)
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1 Polyphosphate is a cofactor for the activation of factor XI by thrombin. Polyphosphates coagulation factor II, thrombin Homo sapiens
2 We now report that polyphosphate potently accelerates factor XI activation by alpha-thrombin, beta-thrombin, and factor XIa and that these reactions are supported by polyphosphate polymers of the size secreted by activated human platelets. Polyphosphates coagulation factor II, thrombin Homo sapiens
3 We now report that polyphosphate potently accelerates factor XI activation by alpha-thrombin, beta-thrombin, and factor XIa and that these reactions are supported by polyphosphate polymers of the size secreted by activated human platelets. Polyphosphates coagulation factor II, thrombin Homo sapiens