Title : Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.

Pub. Date : 2011 Nov 8

PMID : 21970874






2 Functional Relationships(s)
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1 Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels. vandetanib thymidylate synthetase Homo sapiens
2 Finally, most MPM samples displayed detectable levels of EGFR and TS, the variability of which could be used for patients" stratification in future trials with vandetanib-pemetrexed-carboplatin combination. vandetanib thymidylate synthetase Homo sapiens