Pub. Date : 2011 Sep 21
PMID : 21968922
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The GR has been a particularly useful system for studying hsp90 because the receptor must be bound to hsp90 to have an open ligand binding cleft that is accessible to steroid (3). | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | As found in the endogenous GR hsp90 heterocomplex, the GR ligand binding cleft is open and capable of binding steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | If hsp90 dissociates from the GR or if its function is inhibited, the receptor is unable to bind steroid and requires reconstitution of the GR hsp90 heterocomplex before steroid binding activity is restored (4) . | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | This method can be utilized to test the effects of various chaperone cofactors, novel proteins, and experimental hsp90 or GR inhibitors in order to determine their functional significance on hsp90-mediated steroid binding (8-11). | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |